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Antibiotics are the cornerstone of treatment for *Pseudomonas aeruginosa* infections, but here's the catch: it's often resistant to many common antibiotics. This resistance is a major challenge in treating these infections. Doctors typically use a combination of antibiotics to increase the chances of success. Common antibiotics used include aminoglycosides, antipseudomonal penicillins, cephalosporins, and carbapenems. The choice of antibiotics depends on the specific infection, the patient's condition, and the antibiotic susceptibility of the bacteria. Unfortunately, resistance is a growing problem. Some strains of *Pseudomonas aeruginosa* have developed resistance to multiple antibiotics. This is where antimicrobial stewardship programs come into play. These programs help healthcare professionals use antibiotics wisely, minimizing the development of resistance. In severe infections, antibiotics may be administered intravenously (IV) to ensure high concentrations in the bloodstream.